How DrugSeq Solutions Links Uptake to Cellular Response
DrugSeq Solutions is the first platform to connect drug presence and drug effect inside the same single cell.
Our approach combines chemistry, genomics, and bioinformatics into a single seamless workflow:​​​​​
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Smart Conjugation
Small molecules are linked to a cleavable DNA barcode. Once inside the cell, the linker is released, leaving the drug fully active while the barcode stays behind.
Dual Readout Analytics
Every cell delivers two critical insights: how much drug it received and how it responded at the molecular level.
Single-Cell Sequencing
Using standard platforms like 10x Genomics, both the barcode and the cell’s complete transcriptome are captured together.
This dual-readout design overcomes the blind spots of current tools. Unlike fluorescence imaging or bulk mass spectrometry, DrugSeq Solutions preserves the drug’s native activity, scales across thousands of cells, and reveals resistant subpopulations that often drive therapy failure.
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Key advantages:
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Works with most small molecules
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No new hardware or complex workflows required
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Multiplex-ready: test multiple drugs or doses in one run
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Compatible with advanced models like organoids and spatial assays
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With DrugSeq Solutions, researchers gain unprecedented clarity into drug mechanisms, resistance, and efficacy — accelerating discovery and enabling smarter, earlier decisions in drug development.